Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung growth and development.

Mala R Chinoy1

  • 1Lung Development Research Program, Department of Surgery, Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033-0850, USA. mchinoy@psu.edu

Frontiers in Bioscience : a Journal and Virtual Library
|November 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Connexin 43 gene expression in mice with cardiopulmonary developmental defects.

Frontiers in bioscience : a journal and virtual library·2006
Same author

Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs.

Biology of the neonate·2006
Same author

Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: a possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation.

Journal of cellular biochemistry·2005
Same author

Persistent vascular defects in lung allografts attributed to defective endogenous endothelial progenitors.

The Journal of surgical research·2005
Same author

Basic science faculty in surgical departments: advantages, disadvantages and opportunities.

The Journal of surgical research·2005
Same author

Histology-based screen for zebrafish mutants with abnormal cell differentiation.

Developmental dynamics : an official publication of the American Association of Anatomists·2003

Lung organogenesis involves complex cell interactions and gene regulation for proper development. Disruptions can lead to abnormal lung formation like pulmonary hypoplasia.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Lung organogenesis is a complex process involving endoderm and mesoderm interactions.
  • Mammalian lung development begins as outpouchings from the foregut endoderm into the splanchnic mesenchyme.
  • Branching morphogenesis, differentiation, and gene regulation are critical for lung architecture and function.

Purpose of the Study:

  • To review the mechanisms regulating normal lung development and growth.
  • To discuss the role of genes, transcription factors, and signaling molecules in lung organogenesis.
  • To highlight pulmonary hypoplasia as an example of abnormal lung formation.

Main Methods:

  • Review of molecular biology and genetic experimental approaches.
  • Analysis of gene regulation, including homeobox genes and transcription factors.

Related Experiment Videos

  • In vivo and in vitro molecular techniques such as gene targeting and mutagenesis.

    • Main Results:

    • Lung development involves sequential branching and alveolarization from embryonic to postnatal stages.
    • Specific genes and signaling pathways orchestrate lung architecture, growth, and differentiation.
    • Aberrant developmental events can result from exposure to various teratogens.

    Conclusions:

    • Understanding lung organogenesis is crucial for addressing developmental abnormalities.
    • Molecular techniques provide insights into gene function during lung development.
    • Pulmonary hypoplasia serves as a model for studying defects in lung formation.