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Related Experiment Videos

Continuous propofol infusion in 142 critically ill children.

David N Cornfield1, Ken Tegtmeyer, Michael D Nelson

  • 1Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA. cornf001@umn.edu

Pediatrics
|November 29, 2002
PubMed
Summary

Continuous intravenous propofol infusion is safe and effective for sedating critically ill children in pediatric intensive care units. This study found no adverse events associated with its use in 142 patients.

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Area of Science:

  • Pediatric Critical Care Medicine
  • Pharmacology
  • Anesthesiology

Background:

  • Continuous intravenous propofol infusion is increasingly used in pediatric intensive care units (PICUs).
  • Concerns regarding the safety of propofol infusion have been raised by previous case reports.
  • This study aimed to evaluate the safety and efficacy of continuous propofol infusion in critically ill pediatric patients.

Purpose of the Study:

  • To report the clinical experience with continuous intravenous propofol infusion in a cohort of critically ill children.
  • To assess the safety profile of propofol when administered via continuous infusion in a pediatric intensive care setting.

Main Methods:

  • Retrospective case series review of 142 critically ill children.
  • Propofol administered via continuous intravenous infusion, not exceeding 50 microg/kg/min.

Related Experiment Videos

  • Protocol allowed for hourly 1 mg/kg boluses; data collected from PICU and bone marrow transplant units.

    • Main Results:

    • All 142 patients achieved adequate sedation.
    • Continuous propofol infusion was not associated with metabolic acidosis or hemodynamic compromise.
    • No instances of inadvertent extubation or central venous catheter dislodgement were reported.

    Conclusions:

    • Continuous intravenous propofol infusion is a safe and effective method for sedating critically ill infants and children.
    • The study suggests that continuous propofol infusion rates should not exceed 67 microg/kg/min for extended periods.