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Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: an MRS study
Peter H Silverstone1, Tina O'Donnell, Michele Ulrich
1Department of Psychiatry, University Hospital, University of Alberta, Edmonton, Alberta T6G 2B7, Canada. peter.silverstone@ualberta.ca
Human Psychopharmacology
|November 29, 2002
Summary
Dextro-amphetamine increased the phosphoinositol (PI) cycle in humans, as shown by magnetic resonance spectroscopy (MRS). This study confirms the PI cycle
Area of Science:
- Neuroscience
- Biochemistry
Background:
- The phosphoinositol (PI) cycle is crucial for cellular signaling.
- Dextro-amphetamine is a stimulant with known effects on neurotransmitters.
Purpose of the Study:
- To investigate the impact of dextro-amphetamine on the PI cycle in humans.
- To correlate subjective effects with physiological changes.
Main Methods:
- Utilized (1)H and (31)P magnetic resonance spectroscopy (MRS) in 17 healthy volunteers.
- Administered 20 mg oral dextro-amphetamine in an open-label design.
- Collected subjective data using visual analog scales (VAS).
Main Results:
- Significant increases in myo-inositol and phosphomonoester concentrations were observed post-dextro-amphetamine administration.
- These biochemical changes suggest enhanced PI cycle activity.
Conclusions:
- Dextro-amphetamine administration appears to activate the PI cycle in humans.
- This activation is likely mediated indirectly through dopamine and noradrenaline release.
- This is the first human study to demonstrate this effect.