Related Experiment Video
Updated: Aug 10, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Ferrara intrastromal corneal rings for the correction of keratoconus
Dimitrios Siganos1, Paulo Ferrara, Konstantinos Chatzinikolas
1Vlemma Eye Institute, Athens, Greece.
Purpose:
To evaluate the safety and efficacy of Ferrara intrastromal corneal rings in the treatment of eyes with keratoconus without central corneal scarring.
Setting:
Vlemma Eye Institute, Athens, Greece.
Methods:
Twenty-six patients with bilateral keratoconus, clear central corneas, and contact lens intolerance participated in the study. Videokeratographic corneal topography and ultrasonic pachymetry were performed in all eyes to identify the cone area and to select the thickness of the segments to be implanted, respectively. Ferrara intrastromal corneal rings were implanted around the center of the cone in 1 eye of each patient.
Results:
The minimum follow-up after ring implantation was 6 months. In 2 cases, the rings had to be removed early in the postoperative period because of superficial implantation in 1 patient and asymmetrical placement in the other. The rest of the operated eyes demonstrated a reduction in astigmatism and spherical correction and improved uncorrected visual acuity. No eye lost best corrected visual acuity.
Conclusions:
Ferrara intrastromal corneal rings reduced corneal steepening and normalized the central cornea in eyes with keratoconus. Ferrara ring implantation was a safe procedure that may be considered in patients who are unable to have other surgical techniques, particularly contact-lens-intolerant keratoconus patients whose only option is corneal transplantation.

