Related Experiment Video
Updated: Aug 10, 2026

Inducing a Site Specific Replication Blockage in E. coli Using a Fluorescent Repressor Operator System
Published on: August 21, 2016
Stationary phase gene regulation: what makes an Escherichia coli promoter sigmaS-selective?
1Institute of Biology, Microbiology, Freie Universität Berlin, Königin-Luise-Strasse12-16, Berlin, Germany. Rhenggea@zedat.fu-berlin.de
Abstract:
The general stress sigma factor sigma(S) and the vegetative sigma(70) are highly related and recognise the same core promoter elements. Nevertheless, they clearly control different sets of genes in vivo. Recent studies have demonstrated that Esigma(S) selectivity is based on modular combinations of several sequence and structural features of a promoter, to which also trans-acting factors can strongly contribute. These results throw novel light on the details of transcription initiation, as well as on the co-evolution of sigma factors and their cognate promoter sequences.
More Related Videos
Related Concept Videos
Bacterial RNA Polymerase
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...
The Eukaryotic Promoter Region
Inducible Operons: lac Operon
Global Regulatory Systems
Stringent Response in E. coli

