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Updated: Sep 28, 2026
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Suppression of experimental autoimmune uveoretinitis by anti-alphabeta TCR monoclonal antibody
Taeko Inoki1, Satoru Yamagami, Rieko Sakai
1Department of Ophthalmology, Jichi Medical School, Tochigi, Japan.
Purpose:
To evaluate the effects of anti-alphabeta T cell receptor monoclonal antibody (R73) on the induction of experimental autoimmune uveoretinitis (EAU) in rats.
Methods:
Lewis rats in which EAU was induced were treated with R73. All rats were examined for the clinical course of EAU, pathological findings of the globe, delayed-type hypersensitivity, and the interleukin-2 (IL-2) gene and protein expression in the eye.
Results:
The R73 treatment was effective for delaying EAU onset, decreasing the severity of EAU, and suppressing delayed-type hypersensitivity to the antigen. IL-2 gene and protein expression was reduced by R73 treatment in the anterior and posterior segments of the eye.
Conclusion:
R73 treatment is effective for suppression of the development of EAU, inhibiting IL-2 expression in the eye.
