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Related Experiment Videos

Substrate utilization during exercise in postmenopausal women on hormone replacement therapy.

Lisa G Johnson1, Robert R Kraemer, Ginger R Kraemer

  • 1Department of Kinesiology, Louisiana State University, Baton Rouge, LA 70803, USA. ljohns@lsu.edu

European Journal of Applied Physiology
|November 30, 2002
PubMed
Summary

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Hormone replacement therapy (HRT) did not alter substrate utilization during exercise in postmenopausal women. However, exercise itself increased fat utilization over time, regardless of HRT use.

Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Metabolic Health

Background:

  • Menopause-associated decrease in estrogen may increase cardiovascular and metabolic disease risk.
  • Hormone replacement therapy (HRT) may influence body composition and fat distribution in postmenopausal women.
  • Estrogen's potential synergistic effect with exercise on fat mass reduction warrants investigation.

Purpose of the Study:

  • To investigate the influence of HRT on substrate utilization during treadmill exercise in postmenopausal women.
  • To compare substrate utilization between postmenopausal women on HRT and those not on HRT (NHRT).

Main Methods:

  • Eight HRT users and nine NHRT postmenopausal women performed 30 minutes of treadmill exercise at 80% maximal oxygen uptake (VO(2max)).
  • Expired gas analysis determined respiratory exchange ratio (R) and substrate utilization (fat vs. carbohydrate).

Related Experiment Videos

  • Data were analyzed across three 10-minute exercise intervals.

    • Main Results:

    • No significant differences in age, body mass, body fat, or VO(2max) between HRT and NHRT groups.
    • HRT did not affect respiratory exchange ratio, total energy expenditure, or substrate contribution during exercise.
    • Exercise demonstrated a duration-dependent increase in fat utilization, irrespective of HRT status.

    Conclusions:

    • HRT, primarily conjugated equine estrogens, did not alter fat and carbohydrate utilization during moderate-to-vigorous intensity exercise in postmenopausal women.
    • Exercise itself promotes increased reliance on fat oxidation over time in postmenopausal women.
    • Findings suggest that exercise intensity and duration are key factors in substrate utilization during physical activity in this population.