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Developmental immunotoxicology and risk assessment: a workshop summary.

M P Holsapple1

  • 1mholsapple@dow.com

Human & Experimental Toxicology
|December 3, 2002
PubMed
Summary

Developmental immunotoxicology research is nascent, requiring standardized methods for assessing chemical exposures on the developing immune system and informing human risk assessments.

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Area of Science:

  • Developmental immunotoxicology and risk assessment.
  • Comparative immunology and immunosuppression models.
  • Regulatory toxicology and hazard identification.

Background:

  • Growing public concern over early-life exposure to immunotoxic compounds.
  • Need to understand persistent postnatal immunosuppression.
  • Workshop focused on scientific questions in developmental immunotoxicity testing.

Framework:

  • Developing meaningful testing guidelines for developmental immunotoxicity.
  • Addressing critical windows of exposure.
  • Establishing predictive endpoints for immune system effects.

Implementation:

  • Examining scientific questions underlying developmental immunotoxicity tests.
  • Interpreting results for human risk assessment.
  • Applying adult animal model techniques to developing animals.

Implications:

  • Developmental immunotoxicology is an emerging field.
  • Need for strategies to develop standard practices.
  • Uncertainty in relating animal immune system effects to human hazard.

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