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Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives
Lainne E Seitz1, William J Suling, Robert C Reynolds
1Organic Chemistry Department, Southern Research Institute, P.O. Box 55305, Birmingham, Alabama 35255-5305, USA.
Journal of Medicinal Chemistry
|December 3, 2002
Abstract:
A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).