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Related Experiment Videos

Persistent pleocytosis in bacterial meningitis.

S A Chartrand, C T Cho

    The Journal of Pediatrics
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Persistent pleocytosis, an elevated white blood cell count in cerebrospinal fluid, is common in children treated for bacterial meningitis. This finding alone does not warrant extending treatment duration for meningitis.

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    Activity of oral agents against pediatric isolates of Streptococcus pneumoniae.

    Diagnostic microbiology and infectious disease·2001

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Neurology

    Background:

    • Bacterial meningitis requires prompt antibiotic treatment.
    • Cerebrospinal fluid (CSF) analysis is crucial for diagnosis and monitoring.
    • Persistent pleocytosis can complicate treatment assessment.

    Purpose of the Study:

    • To investigate the incidence of persistent pleocytosis in children treated for bacterial meningitis.
    • To determine if persistent pleocytosis indicates a need for prolonged therapy.

    Main Methods:

    • Retrospective analysis of pediatric patients diagnosed with bacterial meningitis.
    • Evaluation of CSF white blood cell counts post-treatment initiation.
    • Categorization based on causative pathogen (e.g., Hemophilus influenzae, Streptococcus pneumoniae).

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    Main Results:

    • Persistent pleocytosis (>60 cells/mm3) was observed in 62% of children with Hemophilus influenzae meningitis (13/21).
    • 22% of children with pneumococcal meningitis (2/9) showed persistent pleocytosis.
    • No clear correlation was established between persistent pleocytosis and the need for extended therapy.

    Conclusions:

    • Persistent pleocytosis is a frequent finding in children adequately treated for bacterial meningitis.
    • Pleocytosis alone is insufficient evidence to prolong antibiotic therapy for bacterial meningitis.
    • The clinical significance of persistent pleocytosis in treated bacterial meningitis remains undetermined.