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Amyloid deposition of systemic myeloma-associated amyloidosis excludes actinic elastotic material
Naoko Wada1, Norihiro Fujimoto, Takehiko Komatsu
1Department of Derrmatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. nwada@xc4.so-net.jp
European Journal of Dermatology : EJD
|December 3, 2002
Abstract:
We report a 65-year-old Japanese man presenting with myeloma-associated systemic amyloidosis. A biopsy specimen taken from the purpuric papules on the periorbital area showed the presence of both amyloid and elastotic materials (actinic elastosis) in the upper dermis. Amyloid deposition and altered elastotic fibers were clearly bordered and never colocalized, and amyloid materials appeared to exclude elastotic materials. The mechanism of this phenomenon is discussed.