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Updated: Jul 26, 2026

A Yeast 2-Hybrid Screen in Batch to Compare Protein Interactions
Published on: June 6, 2018
Hybrid speciation in experimental populations of yeast
Duncan Greig1, Edward J Louis, Rhona H Borts
1The Galton Laboratory, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK.
Abstract:
Most models of speciation require gradual change and geographic or ecological isolation for new species to arise. Homoploid hybrid speciation occurred readily between Saccharomyces cerevisiae and Saccharomyces paradoxus. Hybrids had high self-fertility (about 82%), low fertility when backcrossed to either parental species (about 7.5%), and vigorous growth under different thermal environments that favored one or the other of the parental species. Extensive karyotypic changes (tetrasomy) were observed in the hybrids, although genic incompatibilities accounted for 50% of the variation in self-fertility.
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