Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preimplantation genetic diagnosis.

Peter Braude1, Susan Pickering, Frances Flinter

  • 1Centre for Preimplantation Genetic Diagnosis, Thomas Guy House, Guy's Hospital, London SE1 9RT, UK.

Nature Reviews. Genetics
|December 3, 2002
PubMed
Summary

Preimplantation genetic diagnosis (PGD) offers an alternative to prenatal testing for at-risk couples. This reproductive technology screens embryos for genetic disorders before uterine implantation, aiding family planning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanding the phenotypic spectrum of <i>MECOM</i>-associated syndrome: rare variants are associated with syndromic pulmonary arterial hypertension.

Journal of medical genetics·2026
Same author

Genetic Modifiers of Mendelian Monogenic Collagen IV Nephropathies in Humans and Mice.

Genes·2023
Same author

Correction: The 2019 and 2021 International workshops on Alport syndrome.

European journal of human genetics : EJHG·2023
Same author

A new stoma for an older person-An association with quality of life and physical function: A systematic review.

Journal of the American Geriatrics Society·2022
Same author

The 2019 and 2021 International Workshops on Alport Syndrome.

European journal of human genetics : EJHG·2022
Same author

Guidelines for Genetic Testing and Management of Alport Syndrome.

Clinical journal of the American Society of Nephrology : CJASN·2021

Area of Science:

  • Reproductive genetics
  • Human embryology
  • Medical ethics

Background:

  • Couples at high risk of genetic disorders face difficult reproductive choices.
  • Prenatal diagnosis and pregnancy termination are traditional options.
  • Assisted reproductive technologies offer new avenues for genetic screening.

Purpose of the Study:

  • To describe preimplantation genetic diagnosis (PGD) as an alternative to prenatal testing.
  • To highlight PGD's role in preventing transmission of serious genetic disorders.
  • To discuss the insights and ethical considerations of PGD.

Main Methods:

  • Obtaining genetic samples from oocytes or cleaving embryos.
  • Utilizing in vitro fertilization (IVF) for embryo creation.

Related Experiment Videos

  • Selecting genetically healthy embryos for uterine transfer.

    • Main Results:

    • PGD enables the identification of embryos free from specific genetic disorders.
    • It provides a method to avoid the transmission of hereditary diseases.
    • PGD offers insights into early human development and reproductive genetics.

    Conclusions:

    • Preimplantation genetic diagnosis is a valuable tool for couples at risk of genetic disorders.
    • PGD provides an alternative to prenatal diagnosis, allowing for the selection of unaffected embryos.
    • The advancement of PGD raises significant ethical discussions in assisted reproduction.