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Mohs micrographic surgery for granular cell tumor using S-100 immunostain
Sidney B Smith1, Mary F Farley, John G Albertini
1Department of Dermatology (MCHE-DD), San Antonio Uniformed Health Services Educational Consortium, Brooke Army Medical Center, Fort Sam Houston, Texas 78234, USA.
Summary
Mohs micrographic surgery combined with S-100 staining accurately removed a granular cell tumor (GCT) of the foot. This method improved diagnostic accuracy for nerve extension, ensuring complete tumor removal.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Granular cell tumor (GCT) is a rare neural neoplasm, typically affecting the head and neck, but occasionally found on the foot.
- Diagnosis is confirmed by S-100 protein immunohistochemistry.
- Complete excision is the standard treatment, with limited reports of Mohs micrographic surgery (MMS) for GCT.
Observation:
- This study describes the use of S-100 immunohistochemical staining on MMS frozen sections.
- The objective was to aid in the complete removal of a GCT on the foot with perineural extension.
Findings:
- Mohs micrographic surgery in conjunction with S-100 staining was successfully applied to a plantar foot GCT.
- S-100 staining effectively identified nerve extension not visible with standard H&E staining alone.
Implications:
- Integrating S-100 immunohistochemistry into MMS frozen section analysis enhances diagnostic precision for GCT.
- This approach can improve the accuracy of complete tumor removal, especially in cases with subtle nerve involvement.