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Sildenafil influences lower urinary tract symptoms.
K Sairam1, E Kulinskaya, T A McNicholas
1Lister Hospital Stevenage, and Health Research Support Unit (HRDSU), Hatfiel, Herts, UK.
BJU International
|December 4, 2002
Summary
Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in men are not initially related. However, sildenafil treatment for ED improved LUTS, suggesting a potential benefit for men with both conditions.
Area of Science:
- Urology
- Andrology
- Men's Health
Background:
- Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) are common conditions in aging men.
- The relationship between ED and LUTS, and the impact of ED treatment on LUTS, require further investigation.
Purpose of the Study:
- To evaluate the association between ED and LUTS in men.
- To determine if sildenafil treatment for ED influences LUTS severity.
Main Methods:
- 112 men with ED were treated with oral sildenafil.
- International Index of Erectile Function and International Prostate Symptom Score (IPSS) were administered at baseline and at 1 and 3 months post-treatment.
Main Results:
- No initial correlation was found between baseline sexual function and urinary symptom scores.
- Sildenafil treatment showed a strong correlation between improved sexual function and urinary symptom scores at 3 months.
- A lower baseline IPSS predicted a better response to sildenafil therapy for ED.
Conclusions:
- There is no baseline relationship between sexual function and LUTS in men with ED.
- Sildenafil treatment for ED demonstrated an improvement in LUTS.
- Baseline LUTS severity may predict treatment response to sildenafil for ED.