2,3-Dihydroxyphenethanolamine as an adrenergic agent

In an attempt to further define the role of the m-hydroxy group in adrenergic agents, 2,3-dihydroxyphenethanolamine hydrobromide and N-isopropyl-2,3-dihydroxyphenethanolamine hydrobromide were prepared. These agents are less active than norepinephrine in alpha- and beta-adrenergic in vitro tests. The synthesis and conclusions from the tests are discussed.