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Updated: Sep 28, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
Published on: February 23, 2024
[The influence of recombinant human growth hormones on the systemic metabolism after severe burn]
Zhongyong Chen1, Caizhi Gu, Zhixue Wang
1Department of Burns and Plastic Surgery, Urumchi General Hospital of Lanzhou Command of PLA, Urumchi 830000, P.R. China.
Objective:
To explore the influence of recombinant human growth hormones (rhGH) postburn systemic metabolism.
Methods:
Twenty-four burn patients were randomly and equally divided into treatment and control groups. Same amount of rhGH (9 U/d) or isotonic saline was injected subcutaneously to respective patients during 3 approximately 17 postburn days (PBDs). Blood samples were harvested at 3, 10 and 17 PBDs for the determination of serum growth hormone, insulin-like growth factor (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), serum proteins, plasma insulin, plasma glucagons and blood glucose, which were then compared and analyzed between two the groups.
Results:
The serum levels of GH, IGF-1, IGFBP-3, serum prealbumin and transferrin in rhGH treatment group were evidently higher than those in control groups at 10 and 17 PBDs (P < 0.05 approximately 0.01). But there was no obvious difference in serum albumin, plasma insulin, glucagon and blood glucose (P > 0.05).
Conclusion:
Small dose of rhGH could promote systemic protein synthesis with no side effects on blood glucose levels.
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