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Related Experiment Videos

New insights into skin structure: scratching the surface.

Gopinathan K Menon1

  • 1Avon Products, Inc-Global R&D, Avon Place, Suffern, NY 10901, USA. gopi.menon@avon.com

Advanced Drug Delivery Reviews
|December 4, 2002
PubMed
Summary
This summary is machine-generated.

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The stratum corneum (SC) acts as a smart material, adapting its barrier functions to environmental signals. This review discusses SC

Area of Science:

  • Dermatology and Materials Science

Background:

  • The stratum corneum (SC) is a complex biological barrier.
  • It exhibits unique properties, functioning akin to a 'smart material'.
  • The stratum granulosum (SG) also contributes to active barrier modulation.

Purpose of the Study:

  • To review the formation, structure, and barrier functions of the SC.
  • To discuss the SC's 'smart material' properties and response to environmental cues.
  • To evaluate the use of animal models and ex vivo human skin for transdermal system (TDS) development.

Main Methods:

  • Review of existing literature on stratum corneum formation and function.
  • Analysis of current theories regarding barrier formation.
  • Discussion of methodologies for percutaneous absorption studies.

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Main Results:

  • The SC functions as a composite biopolymer with adaptive barrier capabilities.
  • Environmental signals trigger modulations in SC barrier properties.
  • Limitations exist in extrapolating animal data and using cadaver skin for TDS evaluation.

Conclusions:

  • The stratum corneum's 'smart material' characteristics are crucial for its barrier function.
  • Careful consideration of model systems is needed for accurate transdermal system development.
  • Further research is warranted to fully understand and leverage SC properties for drug delivery.