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Prognostic importance of glomeruloid microvascular proliferation indicates an aggressive angiogenic phenotype in
Oddbjørn Straume1, Pierre O Chappuis, Helga B Salvesen
1Department of Pathology, The Gade Institute, University of Bergen, Bergen 5021, Norway.
Cancer Research
|December 4, 2002
Abstract:
We evaluated the presence of glomeruloid microvascular proliferations (GMPs) in 723 patients with melanomas, breast, endometrial, or prostate cancer. Presence of GMPs was associated with markers of aggressive tumor behavior and significantly reduced survival or increased clinical recurrences in all four of the cancer types in univariate analysis. GMPs were related to increased microvessel density in prostate cancer only. In the case of melanomas, breast, and prostate cancers (but not endometrial cancers), GMPs were a significant prognostic factor in the final multivariate models (P all