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[A patient with polymyalgia rheumatica who exhibited fever as the main symptom for a long period]
Naoko Abe1, Hayato Yamauchi, Takanori Senba
1Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto-city, Hyogo.
Abstract:
We encountered a patient with polymyalgia rheumatica (PMR) who exhibited fever as the main symptom for a long period without muscular pain. As an etiological factor, the condition may have been associated with nonsteroidal anti-inflammatory drugs (NSAIDs). A 71-year-old man consulted our Department of Orthopedics for fever and lumbar pain, which initially developed in early September 2000. Administration of NSAIDs resulted in the disappearance of lumbar pain. However, fever persisted. The C-reactive protein (CRP) level was persistently high. Therefore, on October 5, 2000, the patient was referred to our department. At the outpatient clinic, a detailed examination was performed. However, the etiology could not be determined. Repeated administration of NSAIDs resulted in pyretolysis, and the dose of NSAIDs was decreased from January 31, 2001. Severe fever appeared again, and inflammatory reaction also exacerbated. On March 11, 2001, muscular pain involving the bilateral shoulders and forearms suddenly developed. For diagnostic treatment, administration of prednisolone (PSL) at 10 mg/day was started. Muscular pain rapidly disappeared. According to Bird's criteria, PMR was diagnosed. After the dose of PSL was decreased to 7.5 mg/day, the course is good. PMR should be considered as the etiology of idiopathic fever in elderly patients.
Insights
Polymyalgia rheumatica (PMR) can present with prolonged fever and elevated C-reactive protein (CRP) in elderly patients. This case highlights PMR as a potential cause of unexplained fever, even without initial muscle pain.
Area of Science:
- Rheumatology
- Internal Medicine
Background:
- Polymyalgia rheumatica (PMR) is an inflammatory condition typically presenting with muscle pain and stiffness.
- Fever can be an atypical or initial symptom of PMR, particularly in elderly individuals.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) may temporarily alleviate some symptoms, potentially complicating diagnosis.
Observation:
- A 71-year-old male presented with prolonged fever and elevated C-reactive protein (CRP) without initial muscular complaints.
- NSAID administration provided temporary relief from fever and lumbar pain, but fever persisted.
- Development of shoulder and forearm muscular pain led to a diagnosis of PMR.
Findings:
- The patient was diagnosed with polymyalgia rheumatica (PMR) based on Bird's criteria.
- Treatment with prednisolone (PSL) rapidly resolved muscular pain.
- The case demonstrates that PMR should be considered in the differential diagnosis of idiopathic fever in the elderly.
Implications:
- This case expands the understanding of PMR presentation, emphasizing fever as a primary symptom.
- Highlights the importance of considering PMR in elderly patients with persistent unexplained fever and elevated inflammatory markers.
- Suggests a potential role for NSAIDs in masking or mimicking initial PMR symptoms.
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