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[CD25 positive chronic eosinophilic leukemia with myelofibrosis]
Takashi Saitoh1, Minoru Saiki, Mituru Inoue
1First Department of Internal Medicine, Nihon University School of Medicine.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|December 5, 2002
Summary
This study details a rare case of chronic eosinophilic leukemia in a 70-year-old man, diagnosed by specific blood markers and bone marrow findings. The research highlights the need for further investigation into eosinophil activation in this condition.
Area of Science:
- Hematology
- Oncology
Background:
- A 70-year-old male presented with anemia and thrombocytopenia.
- Physical exam revealed hepatosplenomegaly, with normal skin and neurological findings.
Observation:
- Blood analysis showed elevated white blood cells with 58.5% eosinophils and 3.5% blast cells.
- Flow cytometry revealed eosinophils positive for CD33, CD13, CD25, and HLA-DR.
- Bone marrow biopsy showed severe myelofibrosis with blastoid cells and isochromosome 17.
Findings:
- FISH analysis indicated three signals for RAR alpha (17q21.1) in 62% of peripheral blood nucleated cells.
- BCR/ABL gene rearrangement was not detected.
- Diagnosis of chronic eosinophilic leukemia was established after excluding other conditions.
Implications:
- The patient, despite lacking hypereosinophilia symptoms, showed eosinophil activation markers.
- Elevated soluble IL-2 receptor and eosinophil cationic protein levels suggest activated eosinophils.
- Further research is required to understand eosinophil activation mechanisms in chronic eosinophilic leukemia.