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Updated: Sep 28, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
[Donor cell-derived acute myeloid leukemia developed shortly after allogeneic bone marrow transplantation for MDS
Ryoichi Takahashi1, Chihiro Shimazaki, Tohru Inaba
1Second Department of Medicine, Kyoto Prefectural University of Medicine.
Abstract:
We report a patient with myelodysplastic syndrome (MDS) overt leukemia who developed an acute myeloid leukemia (AML) in donor cells shortly after bone marrow transplantation (BMT) from his HLA-matched sibling. Molecular analysis using microsatellite repeats by polymerase chain reaction proved the new leukemia to be of donor cell origin. The patient received chemotherapy with idarubicin and ara-C, but he died due to mucormycosis.
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