Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Testicular aromatase].

Serge Carreau1, Sonia Bourguiba, Sophie Lambard

  • 1Laboratoire de Biochimie-IRBA, EA 2608-USC INRA, Université de Caen, France.

Journal De La Societe De Biologie
|December 5, 2002
PubMed
Summary

The enzyme cytochrome P450 aromatase (P450arom) produces estrogens in rat germ cells and human sperm. This suggests a role for female hormones in regulating sperm production, particularly in later stages.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An acute exposure to glyphosate-based herbicide alters aromatase levels in testis and sperm nuclear quality.

Environmental toxicology and pharmacology·2014
Same author

Disruption of nongenomic testosterone signaling in a model of spinal and bulbar muscular atrophy.

Molecular endocrinology (Baltimore, Md.)·2012
Same author

Estrogens in male germ cells.

Spermatogenesis·2012
Same author

Role of estrogens in spermatogenesis.

Frontiers in bioscience (Elite edition)·2011
Same author

17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules.

Journal of molecular endocrinology·2011
Same author

Estrogens: new players in spermatogenesis.

Reproductive biology·2011

Area of Science:

  • Biochemistry
  • Reproductive Biology
  • Endocrinology

Context:

  • Cytochrome P450 aromatase (P450arom) catalyzes androgen-to-estrogen conversion.
  • P450arom is crucial for development, reproduction, and various metabolic processes.
  • Estrogen production sites in the male gonad are not fully understood.

Purpose:

  • To investigate the expression and localization of P450arom in male reproductive tissues.
  • To explore the potential role of P450arom in spermatogenesis.

Summary:

  • P450arom gene expression was identified in rat testicular somatic cells via promoters II and I.4.
  • Evidence suggests P450arom is expressed as an active protein in rat germ cells, indicating an additional estrogen production site.
  • P450arom expression was also detected in ejaculated human spermatozoa.
  • Estrogen receptors (ER alpha and ER beta) are widely distributed in testicular cells and the genital tract.

Impact:

  • These findings indicate a physiological role for estrogens in regulating spermatogenesis, especially in postmeiotic stages.
  • The study highlights a novel site of estrogen production within the male gonad.
  • Provides insights into the complex interplay of hormones in male reproductive function.

Related Experiment Videos