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The TB structural genomics consortium: providing a structural foundation for drug discovery
Celia W Goulding1, Marcin Apostol, Daniel H Anderson
1Bioscience Division, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Current Drug Targets. Infectious Disorders
|December 5, 2002
Summary
Structural genomics is accelerating drug discovery by determining protein structures. The tuberculosis (TB) Structural Genomics Consortium aims to map 400 TB proteins, with 28 structures already aiding new therapeutic development.
Area of Science:
- Structural biology
- Genomics
- Drug discovery
Background:
- Structural genomics aims to provide a foundation for drug discovery through large-scale protein structure determination.
- Tuberculosis (TB) poses a significant global health challenge, necessitating novel therapeutic strategies.
Purpose of the Study:
- To establish a structural genomics initiative focused on Mycobacterium tuberculosis proteins.
- To accelerate the discovery of new anti-TB drugs by providing essential structural data.
Main Methods:
- The tuberculosis (TB) Structural Genomics Consortium coordinates and facilitates the determination of protein structures.
- High-throughput structure determination techniques are employed.
Main Results:
- To date, the Consortium has determined the structures of 28 proteins from Mycobacterium tuberculosis.
- These determined protein structures serve as a basis for ongoing drug discovery efforts.
Conclusions:
- Structural genomics is a viable approach to generate critical data for drug discovery.
- The TB Structural Genomics Consortium is making significant progress towards its goal of mapping 400 TB protein structures.
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