Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immune reactions in the eye].

P Esterre1, A Auzemery, P Godinaud

  • 1Unité de Parasitologie, Institut Pasteur de Madagascar, BP 1274, 101 Antananarivo, Madagascar.

Archives De L'Institut Pasteur De Madagascar
|January 1, 1996
PubMed
Summary

The eye, once thought to be immune-privileged, shows antigen presentation in conditions like autoimmune uveitis. Local immunosuppressive mechanisms regulate the immune response to prevent tissue damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Importance of a regional observatory of malarial chemoresistance, an emerging public health problem in the Guyanas region].

Bulletin de la Societe de pathologie exotique (1990)·2009
Same author

Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status.

Parasite (Paris, France)·2006
Same author

[The history of lymphatic filarlasis control programme in French Polynesia: lessons from a 50 years effort].

Bulletin de la Societe de pathologie exotique (1990)·2005
Same author

Soluble cellular adhesion molecules, selectins, VEGF and endothelin-1 in patients with Wuchereria bancrofti infection and association with clinical status.

Parasite immunology·2005
Same author

Morbidity of schistosomiasis mansoni in the highlands of Madagascar and comparison of current sonographical classification systems.

Transactions of the Royal Society of Tropical Medicine and Hygiene·2002
Same author

The impact of 34 years of massive DEC chemotherapy on Wuchereria bancrofti infection and transmission: the Maupiti cohort.

Tropical medicine & international health : TM & IH·2001

Area of Science:

  • Ophthalmology
  • Immunology
  • Neuroscience

Context:

  • The eye and brain are traditionally considered immune-privileged sites.
  • Key features include the blood-ocular barrier, lack of lymphatic drainage, and absence of professional antigen-presenting cells.

Purpose:

  • To challenge the dogma of ocular immune privilege.
  • To highlight recent findings on antigen presentation within the eye.

Summary:

  • Recent studies indicate that endogenous and exogenous antigens are presented in the eye.
  • This occurs in conditions such as autoimmune uveitis and ocular cysticercosis.
  • The local immune response is actively regulated by immunosuppressive mechanisms to mitigate inflammation.

Impact:

  • Revises the understanding of ocular immune privilege.
  • Suggests new therapeutic targets for ocular inflammatory diseases.
  • Emphasizes the complex immune regulation within the eye.

Related Experiment Videos