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Treatment of the SpA-like disease in HLA B27 transgenic animals
1INSERM U567 and Service de Rhumatologie B, Hôpital Cochin, Université René Descartes, Paris, France. maxime.breban@cch.ap-hop-paris.fr
Clinical and Experimental Rheumatology
|December 5, 2002
Abstract:
A major involvement of the immune system and of microbial flora in the HLA-B27 transgenic rat model of spondylarthropathy was demonstrated. The role of inflammatory pathways, such as cytokines and inducible nitric oxide synthase (iNOS) was investigated. Treatment with IL-10 failed to improve established disease, whereas such improvement was achieved with IL-11. In contrast, aggravation was observed after treatment with selective inhibitor of iNOS.
