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Related Experiment Videos

Acoustics of blood plasma on solid surfaces.

Marcus Andersson1, Anders Sellborn, Camilla Fant

  • 1Department of Cell and Molecular Biology/Interface biophysics, Lundberg Laboratory, Göteborg University, Box 462, SE-405 30 Göteborg, Sweden.

Journal of Biomaterials Science. Polymer Edition
|December 5, 2002
PubMed
Summary

This study quantifies blood plasma coagulation on different surfaces using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). Titanium surfaces rapidly initiated coagulation, unlike heparinized surfaces, highlighting material-dependent blood interactions.

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Hematology

Background:

  • Surface interactions with blood plasma are critical for biomaterial performance.
  • Understanding surface-initiated coagulation is essential for preventing thrombosis and improving medical devices.

Purpose of the Study:

  • To quantify surface-associated coagulation of human blood plasma on various materials.
  • To evaluate the efficacy of a novel Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) system for studying blood-surface interactions.

Main Methods:

  • Utilized Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) to measure mass and viscoelastic changes during plasma coagulation.
  • Investigated four surfaces: Heparin (Hep), Titanium (Ti), Polystyrene (PS), and Poly(urethane urea) (PUUR).

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  • Initiated coagulation by adding calcium to plasma and monitored interactions over time.

    • Main Results:

    • Heparinized surfaces showed no clot formation within one hour.
    • Titanium surfaces exhibited rapid changes in frequency shift and viscoelastic properties, indicating early coagulation.
    • Corn trypsin inhibitor (CTI) prolonged coagulation times on non-heparinized surfaces, confirming intrinsic pathway involvement.

    Conclusions:

    • QCM-D is an effective method for studying surface-associated coagulation and screening biomaterials.
    • Material surface properties significantly influence the initiation and progression of blood plasma coagulation.
    • Titanium surfaces demonstrate a strong propensity to activate blood coagulation pathways.