Related Experiment Video
Updated: Aug 5, 2026

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Angiographic concurrence of coronary artery disease and aortoiliac lesions
Alberto Rangel1, Héctor Albarrán, Sergio Solorio
1Servicio de Hemodinamia, Hospital de Especialidades, Centro Medico Nacional La Raza, IMMS, Mexico, DF, Mexico. rangel_albertomx@yahoo.com.mx
Insights
The study found that 40.5% of patients with coronary artery disease also had aortoiliac lesions. Smoking and intermittent claudication were key risk factors for these combined vascular conditions.
Area of Science:
- Cardiovascular Medicine
- Vascular Surgery
- Interventional Cardiology
Background:
- Coronary artery disease (CAD) and aortoiliac disease often coexist, impacting patient morbidity and surgical risk.
- Recognizing this association is crucial for managing patients who may require simultaneous or sequential cardiovascular and peripheral vascular interventions.
Purpose of the Study:
- To determine the frequency of the association between coronary artery disease and aortoiliac lesions.
- To identify and stratify risk factors associated with this comorbidity.
Main Methods:
- Abdominal aortography was performed on 84 patients (65 men, 19 women) with known coronary heart disease.
- Aortoiliac lesions were identified, and coronary artery disease was defined as >50% obstruction in at least one coronary artery.
Main Results:
- Aortoiliac lesions were present in 42.9% of patients; 40.5% had both CAD and aortoiliac lesions.
- Smoking history and intermittent claudication were significantly associated with aortoiliac lesions.
- The extent of coronary artery disease directly correlated with the frequency and severity of aortoiliac lesions.
Conclusions:
- A significant proportion of patients with coronary artery disease also exhibit aortoiliac lesions.
- Smoking and intermittent claudication are important clinical indicators for screening for aortoiliac disease in CAD patients.
- The severity of coronary artery disease is a predictor of the presence and extent of aortoiliac disease.
Abstract:
The importance of recognizing the association between aortoiliac disease and coronary artery disease includes the following: (1) Long-term morbidity is higher and survival ratio poorer in patients with coronary heart disease compared with isolated lower extremity revascularization surgery. (2) Coronary artery bypass grafting is a relatively high-risk procedure in patients with severe vascular disease. (3) There is the prospect that the patient will eventually face simultaneous coronary artery and vascular surgery, or coronary artery angioplasty previous to aortoiliac surgery. The aim of this investigation is to know the frequency of the association of coronary artery disease with aortoiliac lesions and to stratify the risk factors related to such an association. In total, 65 men and 19 women (30 to 76 years of age) with a history of coronary heart disease underwent abdominal aortography after selective coronary artery and left ventricle angiography. Aortoiliac lesions were identified at angiograms. Relevant coronary artery disease was diagnosed when at least 1 coronary artery was obstructed > 50%. The frequency of association between aortoiliac and coronary artery lesions was established, as well as the relationship of these lesions to the following clinical variables: age, weight, height, smoking habit, history of coronary heart disease, systemic arterial hypertension, diabetes mellitus, intermittent claudication, glycemia, uricemia, and triglyceridemia. There were 36 patients (42.9%) with aortoiliac lesions. In 34 patients (40.5%) coronary artery disease was associated with aortoiliac lesions. Abdominal aortic dilations were found in 10 instances, abdominal aortic stenosis in 13 patients, and stenosis of the iliac arteries or their branches on 28 occasions. The variables statistically related to the presence of aortoiliac lesions were smoking habit and a history of intermittent claudication. The number of affected coronary arteries was directly related to the frequency of aortoiliac lesions. In the entire sample, 11 patients (13%) had no coronary artery disease, and 15 (17.9%) had 1-vessel, 24 (28.6%) 2-vessel, and 34 (40.5%) 3-vessel disease. The extent of coronary disease was directly related to the frequency and extent of aortoiliac lesions. Frequencies of aortoiliac lesions were strongly related to a history of smoking habit and intermittent claudication and directly related to the extent of coronary artery disease.
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Coronary Artery Disease III: Clinical Manifestations
Acute Coronary Syndrome III: Diagnostic Studies
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Aneurysm II: Clinical Manifestations and Diagnostic Studies

