Collagen stability, hydration and native state
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Updated: Sep 28, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
Published on: September 20, 2012
Inés G Mogilner1, Graciela Ruderman, J Raúl Grigera
1Departamento de Ciencias Biológicas, Instituto de Física de Líquidos y Sistemas Biológicos (IFLYSIB) CONICET-UNLP-CIC, 59 No. 789 C.C. 565, Facultad de Ciencias Exactas UNLP Universidad Nacional de La Plata, 1900 La Plata, Argentina.
Abstract:
Molecular dynamics simulations of a collagen-like peptide (Pro-Hyp-Gly)4-Pro-Hyp-Ala-(Pro-Hyp-Gly)5 have been done in order to study the contribution of the hydration structure on keeping the native structure of collagen. The simulation shows that the absence of water produces a distortion on the molecular conformation and an increase in the number of intra-molecular hydrogen bonds. This is in agreement with previous experimental results showing the stiffness of collagen under severe drying and its increase in the thermal stability. This dehydrated material does not keep, however, the native structure.
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