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Androgenic function of a granulosa cell tumor
Obstetrics and Gynecology
|January 1, 1976
Summary
Virilizing granulosa cell tumors are rare ovarian tumors that can cause excess male hormone production. Surgical removal of a cystic tumor normalized hormone levels and restored normal reproductive function.
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
- Endocrinology
Background:
- Virilizing granulosa cell tumors (GCTs) are uncommon ovarian neoplasms.
- Hormonal studies on these tumors are limited.
- These tumors can present with signs of hyperandrogenism.
Observation:
- A case of a hirsute woman with a cystic GCT of the ovary is presented.
- Pre- and post-operative plasma hormone levels were analyzed.
- The patient exhibited signs of virilization.
Findings:
- The ovarian tumor was identified as the source of testosterone production.
- Elevated testosterone levels and a high T-index were observed pre-surgery.
- Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were suppressed pre-surgery.
Implications:
- Surgical resection of virilizing GCTs can resolve hyperandrogenism.
- Normalization of hormone levels (testosterone, T-index, LH, FSH) occurs post-operatively.
- Restoration of normal hormonal balance can lead to the resumption of ovulation.