Ligand-gated ion channels in the enteric nervous system

There are many cell surface receptors expressed by neurones in the enteric nervous system (ENS). These receptors respond to synaptically released neurotransmitters, circulating hormones and locally released substances. Cell surface receptors are also targets for many therapeutically used drugs. This review will focus on ligand-gated ion channels, i.e. receptors in which the ligand binding site and the ion channel are parts of a single multimeric receptor. Ligand-gated ion channels expressed by enteric nerves are: nicotinic acetylcholine receptors (nAChRs), P2X receptors, 5-hydroxytryptamine3 (5-HT3) receptors, gamma-aminobutyric acid (GABAA) receptors, N-methyl-d-aspartate (NMDA) receptors,alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and glycine receptors. P2X, 5-HT3 and nAChRs participate in fast synaptic transmission in S-type neurones in the ENS. Fast synaptic transmission occurs in some AH-type neurones, and AH neurones express all the ligand-gated ion channels listed above. Ligand-gated ion channels may be localized at extra-synaptic sites in some AH neurones and these extra-synaptic receptors may be useful targets for drugs that can be used to treat disorders of gastrointestinal function.