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Enteric nerve stimulation evokes a premature colonic migrating motor complex in mouse
1Department of Physiology, Monash University, Clayton, Victoria, Australia. nick@physio.unr.edu
Neurogastroenterology and Motility
|December 5, 2002
Summary
Electrical stimulation of enteric nerves can prematurely trigger colonic migrating motor complexes (CMMCs) in mouse colon. This effect was observed in the mid and distal colon, but not the proximal region.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Physiology
Background:
- Colonic migrating motor complexes (CMMCs) are crucial for gut motility.
- The role of enteric nerve stimulation in initiating CMMCs requires further elucidation.
Purpose of the Study:
- To investigate the effects of enteric nerve stimuli on spontaneous CMMCs in isolated mouse colon.
- To determine if premature CMMCs can be evoked by electrical stimulation of the enteric nervous system.
Main Methods:
- Isolated whole mouse colon preparation maintained at 36°C.
- Recording of circular smooth muscle tension in proximal, mid, and distal colon.
- Electrical stimulation of enteric nerves between spontaneous CMMCs.
Main Results:
- Spontaneous CMMCs were recorded migrating from proximal to distal colon.
- Electrical stimulation of mid and distal colon elicited premature CMMCs in 57% of trials.
- Stimulation of the proximal colon did not evoke premature CMMCs.
Conclusions:
- Enteric nerve stimulation can prematurely evoke CMMCs in the isolated mouse colon.
- Selective activation of ascending neural pathways may be necessary to initiate premature CMMCs.