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Related Experiment Videos

Growth hormone therapy.

J M Wit1

  • 1Department of Paediatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

Best Practice & Research. Clinical Endocrinology & Metabolism
|December 5, 2002
PubMed
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Growth hormone (GH) treatment effectively increases height in children with GH deficiency, but individualized dosing is crucial due to varied responses. Research is ongoing to optimize GH therapy strategies and its use in other short stature conditions.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Childhood Growth Disorders

Background:

  • Growth hormone (GH) has been a cornerstone of treatment for GH deficiency since 1958.
  • Current standard doses (0.23 mg/kg/week) achieve near-target final height but show significant inter-individual variability.
  • Optimizing GH treatment requires exploring individualized dosing strategies and management during puberty.

Purpose of the Study:

  • To review the current understanding and ongoing investigations into growth hormone therapy for children.
  • To evaluate the efficacy and optimal strategies for GH treatment in various short stature conditions.
  • To highlight areas where further research is needed.

Main Methods:

  • Review of existing literature and clinical data on growth hormone substitution therapy.

Related Experiment Videos

  • Analysis of prediction models for individualizing GH dosage.
  • Evaluation of treatment outcomes in different pediatric short stature conditions.

    • Main Results:

    • A dose of 0.23 mg/kg/week is generally effective for GH deficiency, aiming for target height.
    • Individualized dosing strategies and prediction models are under investigation to manage inter-individual response variations.
    • GH shows efficacy in short stature associated with chronic renal failure and Prader-Willi syndrome.
    • The optimal management during puberty remains uncertain.
    • GH therapy yields an average final height gain of 5-7 cm in idiopathic short stature, though its value is debated.
    • Limited data exist for other conditions, but few side-effects are reported.

    Conclusions:

    • Growth hormone therapy is a valuable tool for pediatric short stature, particularly in GH deficiency.
    • Further research is needed to refine individualized dosing and pubertal management strategies.
    • GH is effective in specific conditions like chronic renal failure and Prader-Willi syndrome, with a favorable safety profile.