Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interictal spike EEG source analysis in hypothalamic hamartoma epilepsy.

Alberto J R Leal1, Vitorina Passão, Eulália Calado

  • 1Department of Neurology, Hospital Fernando Fonseca, IC19, 2700 Amadora, Portugal. a.leal@netcabo.pt

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|December 5, 2002
PubMed
Summary

Epilepsy linked to hypothalamic hamartomas originates deep within the brain near the hamartoma, not the cortex. This finding challenges previous assumptions about seizure origins in this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anatomical and physiological basis of continuous spike-wave of sleep syndrome after early thalamic lesions.

Epilepsy & behavior : E&B·2017
Same author

Dynamics of epileptic activity in a peculiar case of childhood absence epilepsy and correlation with thalamic levels of GABA.

Epilepsy & behavior case reports·2016
Same author

Identification of novel genetic causes of Rett syndrome-like phenotypes.

Journal of medical genetics·2016
Same author

Who needs surgery for pediatric myelomeningocele? A retrospective study and literature review.

The journal of spinal cord medicine·2014
Same author

The mismatch negativity (MMN) potential as a tool for the functional mapping of temporal lobe epilepsies.

Epilepsy & behavior : E&B·2014
Same author

Atypical phenotype in two patients with LAMA2 mutations.

Neuromuscular disorders : NMD·2014

Area of Science:

  • Neuroscience
  • Epileptology
  • Medical Imaging

Background:

  • Epilepsy associated with hypothalamic hamartomas presents with unique, often treatment-resistant seizures.
  • This syndrome is characterized by cognitive delays, behavioral issues, and multifocal electroencephalogram (EEG) spike activity.
  • The precise origin of these EEG spikes has been debated, with cortical origins widely assumed.

Observation:

  • This study analyzed interictal spikes in 4 patients (ages 2-25) with epilepsy and hypothalamic hamartoma using EEG and MRI-based models.
  • Multifocal spike activity, primarily in frontal and temporal lobes, was observed.
  • Source analysis employed single moving dipole models and the Rap-MUSIC algorithm.

Findings:

  • EEG spikes were best explained by deep sources near the hamartoma, followed by later cortical involvement.

Related Experiment Videos

  • No patient's spike activity could be solely attributed to cortical sources.
  • Results consistently indicate a subcortical origin for seizure activity.

    • Implications:

    • This research challenges the long-held assumption of cortical origins for seizures in hypothalamic hamartoma epilepsy.
    • Understanding the subcortical origin is crucial for developing more effective therapeutic strategies.
    • Further investigation into deep brain stimulation or other targeted interventions may be warranted.