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Related Experiment Video

Updated: Jul 9, 2026

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

Published on: April 24, 2009

Fimbria-fornix lesions disrupt the dead reckoning (homing) component of exploratory behavior in mice.

Joanna H Gorny¹, Bogdan Gorny, Douglas G Wallace

¹Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 4N6, Canada.

Learning & Memory (Cold Spring Harbor, N.Y.)

|December 5, 2002

Summary

Mice can now explore from a home base using a new method. Fimbria-fornix lesions impaired direct returns, suggesting this brain area aids dead reckoning in spatial exploration.

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Last Updated: Jul 9, 2026

A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

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Published on: October 27, 2020

Area of Science:

Neuroscience
Animal Behavior
Spatial Cognition

Background:

Rodent exploration is key for spatial understanding.
The hippocampus is crucial for spatial behavior, but its role in mice is hard to study.
Mice typically don't form home bases in new environments.

Purpose of the Study:

Develop a mouse task for home-base-centered exploration.
Assess the organization of mouse exploratory behavior.
Investigate the impact of fimbria-fornix lesions on exploration.

Main Methods:

Mice used nesting material on a table as a home base.
Exploratory trips, stops, and returns were recorded and analyzed.
Fimbria-fornix lesions were compared to controls in light and dark.

Main Results:

Control mice explored from their bedding with circuitous outward trips and direct returns.
Mice with fimbria-fornix lesions showed similar bedding-centered behavior but fewer direct returns.
Direct homeward trips suggest a dead-reckoning strategy was disrupted by lesions.

Conclusions:

The home-bedding method successfully establishes a home base for mice.
Fimbria-fornix lesions impair the homeward navigation component of exploration.
The fimbria-fornix likely plays a role in dead reckoning for mice.