Related Experiment Video
Updated: Aug 2, 2026
10:09
Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease
Published on: February 14, 2012
Hypersexuality after pallidal surgery in Parkinson disease
David M Roane1, Mi Yu, Todd E Feinberg
1Department of Psychiatry, Beth Israel Medical Center, New York, New York, USA. droane@bethisraelny.org
Neuropsychiatry, Neuropsychology, and Behavioral Neurology
|December 5, 2002
Summary
Patients with Parkinson disease (PD) may develop neuropsychiatric symptoms after pallidal surgery. Antiparkinson medication may increase the risk of psychiatric side effects following this procedure.
Area of Science:
- Neuroscience
- Neurosurgery
- Psychiatry
Background:
- Parkinson disease (PD) frequently presents with diverse psychiatric symptoms.
- Differentiating PD-related psychiatric issues from treatment-induced syndromes is crucial for effective patient management.
Observation:
- A case study involving a Parkinson disease patient who underwent pallidotomy.
- The patient developed a psychiatric syndrome, notably hypersexuality, post-implantation of a deep brain stimulator in the globus pallidus.
Findings:
- Pallidal surgery in Parkinson disease patients carries a risk of neuropsychiatric sequelae.
- Antiparkinson medications may exacerbate this risk, leading to psychiatric side effects.
Implications:
- This case highlights the need for careful monitoring of psychiatric symptoms in PD patients post-pallidal surgery.
- Clinicians should consider potential medication interactions and surgical effects on mental health.
More Related Videos
Related Concept Videos
01:37Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
01:15Parkinson's Disease: Overview
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
01:24Parkinson's Disease: Treatment
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
01:24Parkinson Disease l: Introduction
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
01:24Parkinson Disease ll: Pathophysiology
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
01:11Alterations in Muscle Tone lll
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...