Related Experiment Video
Updated: Sep 28, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
Published on: June 6, 2025
Donor management in cardiac transplantation
Diego H Delgado1, Vivek Rao, Heather J Ross
1Toronto General Hospital, University of Toronto, Toronto, Canada.
Insights
Improving organ donor identification and management is crucial for increasing heart transplantation rates in Canada. Strategies include better donor assessment and utilizing marginal donors to address the critical shortage.
Area of Science:
- Cardiology
- Transplant Surgery
- Public Health
Background:
- Organ donor availability is a significant constraint in organ transplantation.
- Canada experiences low organ donation rates, creating a critical mismatch for heart transplant candidates.
- The demand for heart transplants is rising while donor numbers remain stagnant.
Purpose of the Study:
- To summarize the identification, evaluation, and management of heart transplant donors.
- To define strategies for enhancing organ procurement activities in Canada.
- To address the critical shortage of available organs for heart transplantation.
Main Methods:
- Review of current practices in donor identification and assessment.
- Analysis of strategies to improve medical management of potential donors.
- Evaluation of techniques for utilizing marginal donors and novel organ preservation methods.
Main Results:
- Improved donor identification and assessment can expand the donor pool.
- Enhanced medical management of potential donors may increase organ suitability.
- Marginal donor utilization and advanced preservation techniques show promise for increasing transplant numbers.
Conclusions:
- Optimizing donor identification, evaluation, and management is essential for increasing heart transplant capacity.
- Implementing strategies to improve organ procurement is vital to meet the growing demand for heart transplants in Canada.
- Addressing the donor shortage requires a multi-faceted approach including better donor pool management and innovative transplant technologies.
Abstract:
The most important limitation in organ transplantation is donor availability. Canada is facing a serious situation with respect to organ donation rates and transplantation. The number of patients listed for heart transplant continues to increase while the number of available donors has plateaued. Several steps can be taken to address this growing mismatch. The proper identification and assessment of potential donors together with improvements in medical management may increase the donor pool. Additionally, the use of marginal donors and the development of new organ preservation techniques may lead to an increase in the number of potential heart transplants in Canada. This paper summarizes the identification, evaluation and management of heart transplant donors, and defines strategies to improve procurement activity in heart transplantation.
Related Concept Videos
Kidney Transplant I: Introduction
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant II: Surgical Procedure
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

