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Further case of paroxysmal exercise-induced dystonia and some insights into pathogenesis
Michael H Barnett1, Paul R Jarman, Simon J R Heales
1National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, United Kingdom.
Abstract:
Cerebrospinal fluid (CSF) analysis of pterin and monamine metabolites was performed before and after an attack in a patient with paroxysmal exercise-induced dystonia. A twofold increase in CSF homovanillic acid and 5-hydroxyindoleacetic acid after an attack was measured. This finding lends support to the hypothesis that increased dopaminergic transmission contributes to the clinical features of the hyperkinetic movement disorders.