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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Detection of oncogenes in the diagnosis of cancers with active oncogenic signaling

Toshinari Minamoto1, Andrei V Ougolkov, Masayoshi Mai

  • 1Division of Diagnostic Molecular Oncology, Cancer Research Institute, Kanazawa University, 13-1, Takara-machi, Kanazawa 920-0934, Japan. minamot@kenroku.kanazawa-u.ac.jp

Expert Review of Molecular Diagnostics
|December 6, 2002
PubMed

Insights

Researchers are exploring molecular oncology to reduce cancer risk. This review focuses on K-ras and beta-catenin oncogenes for improved cancer diagnosis and prevention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer research aims to reduce susceptibility and anxiety regarding cancer development.
  • Advances in molecular oncology and technology are crucial for progress.
  • Colorectal, pancreatic, and lung cancers share molecular characteristics, making them key targets.

Purpose of the Study:

  • To review recent knowledge on molecular diagnosis of sporadic cancers.
  • To focus on the roles of K-ras and beta-catenin oncogenes in cancer.
  • To highlight the potential of targeting these oncogenes for cancer prevention and treatment.

Main Methods:

  • Review of current scientific literature on molecular oncology.
  • Focus on K-ras and beta-catenin genes.
  • Analysis of their roles in cell adhesion and transformation.

Main Results:

  • K-ras is a well-documented oncogene altered in target cancers.
  • Beta-catenin is highlighted for its roles in cell adhesion and transformation.
  • Molecular diagnosis targeting these oncogenes shows promise.

Conclusions:

  • Targeting K-ras and beta-catenin oncogenes offers promising avenues for cancer diagnosis and susceptibility assessment.
  • This approach can lead to improved cancer treatment and prevention strategies.
  • Advancements in molecular oncology contribute significantly to human healthcare.

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