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Practical total synthesis of ciguatoxin CTX3C by improved protective group strategy
Masayuki Inoue1, Hisatoshi Uehara, Megumi Maruyama
1Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Organic Letters
|December 6, 2002
Abstract:
[structure: see text] Ciguatoxin CTX3C is a representative congener of ciguatoxins, which are known to be the principal causative agents of ciguatera seafood poisoning. The structure of CTX3C spans more than 3 nm and is characterized by 13 ether rings. In this paper, an improved total synthesis of CTX3C is reported. Alteration of the protective group from benzyl ether to 2-naphthylmethyl (NAP) ether drastically increases the yield for final global deprotection and has provided a sufficient amount of sample for further biological studies.