Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postoperative ileus: progress towards effective management.

Kathrine Holte1, Henrik Kehlet

  • 1Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark. katherine.holte@dadlnet.dk

Drugs
|December 6, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of perioperative enhanced recovery after surgery pathway management versus traditional management on the clinical outcomes of laparoscopic-assisted radical resection of distal gastric cancer: study protocol for a randomized controlled trial.

Trials·2020
Same author

Postoperative 30-day complications after cemented/hybrid versus cementless total hip arthroplasty in osteoarthritis patients > 70 years.

Acta orthopaedica·2020
Same author

Stress dose steroids-take another look at the literature.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2020
Same author

Enhanced recovery after surgery components and perioperative outcomes: a nationwide observational study.

British journal of anaesthesia·2020
Same author

N-Methyl-D-Aspartate Antagonists and Steroids for the Prevention of Persisting Post-Surgical Pain After Thoracoscopic Surgeries: A Randomized Controlled, Factorial Design, International, Multicenter Pilot Trial.

Journal of pain research·2020
Same author

ERAS guidelines for hip and knee replacement - need for reanalysis of evidence and recommendations?

Acta orthopaedica·2020
Same journal

Ecnoglutide: First Approvals.

Drugs·2026
Same journal

The Long Road to Long-Acting: What Oral PrEP and CAB-LA Teach Us About Scaling Lenacapavir.

Drugs·2026
Same journal

Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

Drugs·2026
Same journal

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same journal

Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

Drugs·2026
Same journal

Relacorilant: First Approval.

Drugs·2026
See all related articles

Postoperative ileus (PI) is complex. Continuous epidural analgesia with local anesthetics and multimodal rehabilitation programs are effective strategies for preventing and managing PI.

Area of Science:

  • Gastroenterology
  • Surgical Research
  • Anesthesiology

Background:

  • Postoperative ileus (PI) pathogenesis is multifactorial, involving inhibitory reflexes, inflammatory mediators, and opioids.
  • Current prevention strategies for PI vary in effectiveness.
  • Minimally invasive surgery and epidural analgesia show promise in reducing PI.

Purpose of the Study:

  • To review the multifactorial pathogenesis of postoperative ileus (PI).
  • To evaluate the effectiveness of various strategies in preventing and treating PI.
  • To highlight promising new therapeutic approaches for PI.

Main Methods:

  • Literature review of studies on PI pathogenesis and management.
  • Analysis of the impact of surgical techniques, anesthesia, and pharmacological agents on PI.

Related Experiment Videos

  • Assessment of multimodal rehabilitation programs for PI.

    • Main Results:

    • Continuous postoperative epidural analgesia with local anesthetics is highly effective in preventing PI.
    • Minimally invasive surgery reduces PI by mitigating inflammatory responses.
    • Pharmacological agents for PI treatment have shown limited efficacy or applicability; peripheral opioid antagonists are promising.
    • Multimodal rehabilitation may reduce PI duration post-colonic surgery.

    Conclusions:

    • Effective PI management requires addressing its multifactorial nature.
    • Continuous epidural analgesia and multimodal rehabilitation are key strategies for PI prevention and reduction.
    • Further research into novel agents like peripheral opioid antagonists is warranted.