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Updated: Aug 19, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report
Madhu R Agarwal1, Bita Esmaeli, Michael A Burnstine
1Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Objective:
To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer.
Design:
Interventional case report.
Methods:
A full-thickness section of canaliculus was obtained during surgical repair.
Main Outcome Measure:
Histopathologic changes in the specimen.
Results:
The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen.
Conclusion:
Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
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