Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interlaminar connections in the neocortex.

Alex M Thomson1, A Peter Bannister

  • 1Department of Physiology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK. alext@rfc.ucl.ac.uk

Cerebral Cortex (New York, N.Y. : 1991)
|December 6, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.

PLoS biology·2024
Same author

Circuits and Synapses: Hypothesis, Observation, Controversy and Serendipity - An Opinion Piece.

Frontiers in neural circuits·2021
Same author

Data-driven integration of hippocampal CA1 synaptic physiology in silico.

Hippocampus·2020
Same author

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow.

PLoS computational biology·2018
Same author

Cornu Ammonis Regions-Antecedents of Cortical Layers?

Frontiers in neuroanatomy·2017
Same author

γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.

The Journal of biological chemistry·2016
Same journal

A neuroimaging meta-analysis on social impression formation of stable characteristics.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

An expanded cortical map of von Economo neurons in the human medial prefrontal cortex.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

For better and worse: neural self-partner overlap during social feedback is associated with relationship satisfaction and depressive symptoms.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Regions in the human inferior temporal gyrus are engaged in numerosity processing across visual stimulus categories.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Differentiation of cortical areas: effects of free energy minimization with broken symmetry.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Prior exposure to speech rapidly modulates cortical processing of high-level linguistic structure.

Cerebral cortex (New York, N.Y. : 1991)·2026
See all related articles

This review details local circuit and interlaminar connections in the adult mammalian neocortex. Specific neuronal targets are identified for forward and backward projections, revealing distinct patterns in cortical circuitry.

Area of Science:

  • Neuroscience
  • Cellular Neuroscience
  • Systems Neuroscience

Background:

  • The adult mammalian neocortex exhibits complex local circuit and interlaminar connections.
  • Anatomical techniques initially revealed the spatial precision of these neural circuits.

Purpose of the Study:

  • To review and synthesize current understanding of local circuit and interlaminar connections in the adult mammalian neocortex.
  • To detail the specific neuronal targets of these projections and emerging patterns.

Main Methods:

  • Review of anatomical studies demonstrating spatial precision.
  • Analysis of studies combining paired/triple intracellular recordings with dye-filling.
  • Examination of afferent inputs and efferent outputs for each cortical layer.

Related Experiment Videos

Main Results:

  • Forward projections (Layer 4 to 3, Layer 3 to 5) target pyramidal cells and interneurons.
  • Backward projections (Layer 5 to 3, Layer 3 to 4) exclusively target interneurons.
  • Emerging patterns indicate differential targeting based on projection direction.

Conclusions:

  • Local circuit and interlaminar connections in the neocortex display specific and directional targeting.
  • Understanding these connections is crucial for deciphering cortical information processing.
  • Further research integrating anatomical and physiological data will refine our knowledge of neocortical circuitry.