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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Halting the progression of chronic nephropathy
Ruth C Campbell1, Piero Ruggenenti, Giuseppe Remuzzi
1Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
Journal of the American Society of Nephrology : JASN
|December 6, 2002
Summary
The global incidence of end-stage renal disease (ESRD) is rising, necessitating early nephropathy identification and treatment. Advances in understanding and treating chronic kidney disease offer hope for slowing, and potentially reversing, its progression.
Area of Science:
- Nephrology
- Public Health
Background:
- Global incidence of end-stage renal disease (ESRD) is increasing.
- ESRD presents a significant financial and societal burden due to rising patient numbers requiring renal replacement therapy.
- There is a critical need for early detection and intervention in nephropathy to prevent progression to ESRD.
Purpose of the Study:
- To highlight the growing global burden of end-stage renal disease (ESRD).
- To emphasize the importance of early identification and treatment of nephropathy.
- To review advances in understanding and treating chronic kidney disease.
Main Methods:
- Review of global trends in end-stage renal disease (ESRD) incidence.
- Analysis of the impact of ESRD on healthcare systems and productivity.
- Synthesis of recent research on the progression of diabetic and nondiabetic proteinuric nephropathy.
Main Results:
- End-stage renal disease (ESRD) incidence is increasing worldwide, with significant projected rises in patient numbers.
- Effective treatments are available to slow the progression of chronic kidney disease.
- Research has advanced the understanding of nephropathy progression.
Conclusions:
- Early identification and treatment of nephropathy are crucial to combat the rising tide of end-stage renal disease (ESRD).
- Current research offers promising therapeutic strategies to slow or potentially reverse chronic kidney disease progression.
- Continued research is vital for managing and mitigating the impact of ESRD globally.
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