Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

4,1',6'-Trichloro-4,1',6'-trideoxysucrose monohydrate.

Anthony Linden1, A S Muhammad Sofian, C Kuan Lee

  • 1Institute of Organic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. alinden@oci.unizh.ch

Acta Crystallographica. Section C, Crystal Structure Communications
|December 6, 2002
PubMed
Summary

This study reveals the distinct molecular conformation of a chlorinated sugar derivative at 160 K. Its structure differs significantly from sucralose, featuring unique hydrogen bonding patterns in a 3D framework.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elusive Interplay of 3D Structural Similarity and Twinning in Mechanical Flexibility of Luminescent Organic Crystals.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Transformations of thiocarbonyls into alkenes via Barton-Kellogg olefination.

Acta crystallographica. Section C, Structural chemistry·2025
Same author

Syntheses of Structurally Complex Marine Cyclopropyl-Diterpenoids: Peyssonnoside A and Its Aglycon.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Functional biosynthetic stereodivergence in a gene cluster via a dihydrosydnone N-oxide.

Communications chemistry·2024
Same author

Control over Anion Coordination on Pd(II), Cu(I), and Ag(I) with Regioisomeric Phosphine-Carboxylate Ligands.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

Stereochemical Stability of Planar-Chiral Benzazepine Tricyclics: Inversion Energies of P- and S-Alkene Ligands.

The Journal of organic chemistry·2023

Area of Science:

  • Carbohydrate Chemistry
  • Crystallography
  • Structural Biology

Background:

  • Understanding the three-dimensional structure of modified sugars is crucial for predicting their properties and applications.
  • Sucralose, a widely used artificial sweetener, serves as a reference for comparing structural features of related compounds.

Purpose of the Study:

  • To elucidate the specific molecular conformation of 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-glucopyranoside monohydrate at low temperatures.
  • To compare the structural characteristics and hydrogen bonding patterns with those of sucralose.

Main Methods:

  • Single-crystal X-ray diffraction analysis at 160 K.
  • Conformational analysis of the glucopyranosyl and fructofuranosyl rings.
  • Analysis of intra- and intermolecular hydrogen bonding networks.

Related Experiment Videos

Main Results:

  • The glucopyranosyl ring adopts a near-ideal (4)C(1) chair conformation.
  • The fructofuranosyl ring exhibits a (4)T(3) conformation.
  • Significant differences in conformation around the glycosidic linkage were observed compared to sucralose, influencing intramolecular hydrogen bonding.

Conclusions:

  • The chlorinated sugar derivative forms an extensive three-dimensional framework through complex intermolecular hydrogen bonds involving sugar and water molecules.
  • The distinct conformational features and hydrogen bonding patterns suggest unique chemical and physical properties compared to sucralose.