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Bacterial CpG-DNA licenses TLR9
1Institute for Medical Microbiology, Hygiene and Immunology, Trogerstrasse 9, 81675 Munich, Germany. stefan.bauer@lrz.tum.de
Current Topics in Microbiology and Immunology
|December 7, 2002
Abstract:
The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported. This review focuses on TLR9 which is an essential component for the recognition of bacterial CpG-DNA. Expression of TLR9 and structural consideration as well as direct ligand interaction of TLR9 and CpG-DNA are discussed.