Forced limb-use and recovery following brain injury

Animals subjected to exercise display significant alterations in brain function and neurochemistry, reflecting the innate plasticity of the adult brain to environmental challenges. Following injury, the brain is sensitive to reorganization and regeneration, and thus may be primed for influence by external behavioral demand such as increased use of an injured forelimb. The focus of this review is on the effects of altered use of the impaired forelimb in unilateral rodent models of brain injury. Both the benefits of increased use and the detrimental effects of decreased use following injury will be discussed.