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Hepatoprotective pyrrole derivatives of Lycium chinense fruits
Young-Won Chin1, Song-Won Lim, Seok-Ho Kim
1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, South Korea.
Bioorganic & Medicinal Chemistry Letters
|December 7, 2002
Abstract:
As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4 and 65.8%, respectively).