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Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands
Argyrios G Arvanitis1, Joseph T Rescinito, Charles R Arnold
1Discovery Chemistry-Wilmington, Bristol-Myers Squibb Company, Experimental Station, DE 19880, USA. argyrios.arvanitis@bms.com
Bioorganic & Medicinal Chemistry Letters
|December 7, 2002
Abstract:
A series of high affinity CRF receptor ligands with an imidazo[4,5-c]pyridine core is described. Individual analogues were synthesized and tested in vitro in rat brain receptors to determine binding affinity. The best compound was further tested in the dog N-in-1 pharmacokinetic model to assess oral bioavailability at 1 mg/kg po.