Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic and cellular events: the last frontier?

P G Morris1

  • 1Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, University Park, NG7 2RD, Nottingham, UK. p.morris@nottingham.ac.uk

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|December 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Palbociclib with adjuvant endocrine therapy in early breast cancer: 5-year follow-up analysis of the global multicenter, open-label, randomized phase III PALLAS trial (ABCSG-42/AFT-05/PrE0109/BIG-14-13).

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

CTRIAL-IE (ICORG) 15-34: The impact of the 21 gene breast recurrence score® assay on chemotherapy prescribing in oestrogen receptor positive, lymph node positive early stage breast cancer in Ireland.

Irish journal of medical science·2025
Same author

Irish national real-world analysis of the clinical and economic impact of 21-gene oncotype DX® testing in early-stage, 1-3 lymph node-positive, oestrogen receptor-positive, HER2-negative, breast cancer.

Breast cancer research and treatment·2024
Same author

Illness representations of people with later-onset functional seizures.

Epilepsy & behavior : E&B·2024
Same author

The role of infiltrating lymphocytes in the neo-adjuvant treatment of women with HER2-positive breast cancer.

Breast cancer research and treatment·2021
Same author

An exploration of the impact of ethanol diluent on breath alcohol concentration in patients receiving paclitaxel chemotherapy.

Cancer chemotherapy and pharmacology·2021
Same journal

Commentary on: The American Society of Clinical Psychopharmacology task force consensus statement on the deprescribing of stimulant medications in adults with ADHD.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same journal

Corrigendum to "Functioning assessment short test for autism (FAST-A): a tool to evaluate adaptive functioning in autistic adults" [European Neuropsychopharmacology, 112, 112887].

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same journal

Genomic relationship between polyendocrine metabolic ovarian syndrome and bipolar disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same journal

Genetic overlap between depression and C-reactive protein levels: Evidence from a cross-trait analysis.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same journal

Variability in AI-generated psychedelic definitions across major chatbots.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same journal

In-patient treatment and structural dysconnectivity in major depression - A longitudinal connectome study.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
See all related articles

Functional magnetic resonance imaging (fMRI) tracks neural activity, but its temporal resolution is limited. Combining fMRI with electromagnetic methods or using functional magnetic resonance spectroscopy (MRS) offers finer time-scales and metabolic insights into brain function.

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Biophysics

Background:

  • Functional magnetic resonance imaging (fMRI) is used to observe neural activity patterns.
  • The haemodynamic response's latency limits fMRI's temporal resolution.
  • Electromagnetic techniques like MEG and EEG can complement fMRI for finer time-scales.

Purpose of the Study:

  • To explore and illustrate the use of fMRI for tracking neural activity sequences.
  • To investigate methods for improving the temporal resolution of fMRI.
  • To quantify the energy cost of brain activation using functional magnetic resonance spectroscopy (MRS).

Main Methods:

  • Utilizing ultra-high-speed fMRI sequences.
  • Combining fMRI with electromagnetic techniques (MEG or EEG).

Related Experiment Videos

  • Employing functional magnetic resonance spectroscopy (MRS) with [1-(13)C]glucose infusion to measure tricarboxylic acid cycle rates.

    • Main Results:

    • fMRI was applied to auditory hallucinations and short-term memory paradigms.
    • A 50% increase in tricarboxylic acid cycle flux was observed during visual activation using MRS.
    • Glucose consumption during activation was found to be primarily oxidative.
    • Glutamine synthesis rates were measured to estimate neurotransmitter glutamate recycling.

    Conclusions:

    • Combining fMRI with other techniques enhances temporal resolution for studying neural activity.
    • MRS provides quantitative metabolic data, revealing the energy demands and oxidative nature of brain activation.
    • These methods offer insights into brain energy metabolism and neurotransmitter cycling.